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Creators/Authors contains: "Lindsten, Fredrik"

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  1. ; ; ; ; ; ; ; ; ; ; et al (, Nature Methods)
    Abstract Detecting microsecond structural perturbations in biomolecules has wide relevance in biology, chemistry and medicine. Here we show how MHz repetition rates at X-ray free-electron lasers can be used to produce microsecond time-series of protein scattering with exceptionally low noise levels of 0.001%. We demonstrate the approach by examining Jɑ helix unfolding of a light-oxygen-voltage photosensory domain. This time-resolved acquisition strategy is easy to implement and widely applicable for direct observation of structural dynamics of many biochemical processes. 
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  2. ; ; (, Journal of the American Statistical Association)
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